解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
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整形外科学
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病理学
儿科学
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药理学和药剂学
生理学
基本医疗保健
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放射学,核医学和医学成像
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热带医学
泌尿学和肾脏学
病毒学
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健康政策和服务
心理学,临床
abstract::The functional levels of biological cells or organisms can be separated into the genome, transcriptome, proteome and metabolome. Of these the metabolome offers specific advantages to the investigation of the phenotype of biological systems. The investigation of the metabolome (metabolomics) has only recently appeared ...
journal_title:Physical biology
pub_type: 杂志文章,评审
doi:10.1088/1478-3975/5/1/011001
更新日期:2008-02-20 00:00:00
abstract::A model of ligand-induced intracellular calcium (Ca2+) responses incorporating phospholipase C (PLC) and protein kinase C (PKC) is developed for the purpose of understanding the mechanisms underlying the observed temporal patterns of intracellular calcium (Ca(i)2+) under sustained agonist stimulation. Some studies hav...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/4/4/009
更新日期:2007-12-13 00:00:00
abstract::Cells respond to the environment by regulating the expression of genes according to environmental signals. The relation between the input signal level and the expression of the gene is called the gene regulation function. It is of interest to understand the shape of a gene regulation function in terms of the environme...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/4/4/001
更新日期:2007-11-07 00:00:00
abstract::We present a new particle tracking software algorithm designed to accurately track the motion of low-contrast particles against a background with large variations in light levels. The method is based on a polynomial fit of the intensity around each feature point, weighted by a Gaussian function of the distance from th...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/4/3/008
更新日期:2007-10-09 00:00:00
abstract::The tripartite synapse denotes the junction of a pre- and postsynaptic neuron modulated by a synaptic astrocyte. Enhanced transmission probability and frequency of the postsynaptic current-events are among the significant effects of the astrocyte on the synapse as experimentally characterized by several groups. In thi...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/4/1/001
更新日期:2007-01-09 00:00:00
abstract::Voltage-dependent ion channels determine the electric properties of axonal cell membranes. They not only allow the passage of ions through the cell membrane, but also contribute to an additional charging of the cell membrane resulting in the so-called capacitance loading. The switching of the channel gates between an ...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/3/4/002
更新日期:2006-11-22 00:00:00
abstract::Computer simulations of beta-hairpin folding are relatively difficult, especially those based on the explicit water model. This greatly limits the complete analysis and understanding of their folding mechanisms. In this paper, we use the generalized Born/solvent accessible implicit solvent model to simulate the foldin...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/3/3/001
更新日期:2006-08-24 00:00:00
abstract::Self-organization processes in multicellular aggregates of bacteria and amoebae offer fascinating insights into the evolution of cooperation and differentiation of cells. During myxobacterial development a variety of spatio-temporal patterns emerges such as counterpropagating waves of cell density that are known as ri...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/3/2/006
更新日期:2006-06-23 00:00:00
abstract::In addition to serving as structural elements and as tracks for motor proteins, microtubules use chemical energy derived from the hydrolysis of GTP to generate forces when growing and shrinking. These forces are used to push or pull on organelles such as chromosomes and the mitotic spindle. If an array of microtubules...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/3/1/006
更新日期:2006-02-28 00:00:00
abstract::Peptoids of alpha- and beta-peptides (alpha- and beta-peptoids) can be obtained by shifting the amino acid side chains from the backbone carbon atoms of the monomer constituents to the peptide nitrogen atoms. They are, therefore, N-substituted poly-glycines and poly-beta-alanines, respectively. Due to the substituted ...
journal_title:Physical biology
pub_type: 杂志文章,评审
doi:10.1088/1478-3975/3/1/S01
更新日期:2006-02-02 00:00:00
abstract::We investigate a novel approach for studying protein folding that has evolved from robotics motion planning techniques called probabilistic roadmap methods (PRMs). Our focus is to study issues related to the folding process, such as the formation of secondary and tertiary structures, assuming we know the native fold. ...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/2/4/S09
更新日期:2005-11-09 00:00:00
abstract::Chemotaxis is the process by which cells sense changes in their chemical environment and move towards more favorable conditions. In divergent species of bacteria, the chemotaxis proteins localize to the poles of the cell and information is transferred to the flagellar motors through the phosphorylation of a soluble pr...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/2/3/002
更新日期:2005-07-14 00:00:00
abstract::Protein-protein interactions are central to biology and, in this 'post-genomic era', prediction of these interactions has become the goal of many computational efforts. Close inspection of even relatively simple biological regulatory circuitry reveals multiple levels of control of the contributing protein interactions...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/2/2/S07
更新日期:2005-06-01 00:00:00
abstract::Gene-regulation networks contain recurring elementary circuits termed network motifs. It is of interest to understand under which environmental conditions each motif might be selected. To address this, we study one of the most significant network motifs, a three-gene circuit called the coherent feed-forward loop (FFL)...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3975/2/2/001
更新日期:2005-06-01 00:00:00
abstract::We study the applicability of Van Kampen's linear noise approximation to the calculation of fluctuations in cells due to small number of molecules for simple genetic systems not previously considered. These systems include dimer formation and feedback. We explain why the linear noise approximation can be surprisingly ...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3967/1/4/002
更新日期:2004-12-01 00:00:00
abstract::Based on recent experimental data, we design a model for neuronal membrane potentials that incorporates the influence of the surrounding glia (dressed neurons). A neurotransmitter released into the synaptic cleft triggers a Ca(2+) response in nearby glial cells that spreads as a Ca(2+) wave and interacts with other sy...
journal_title:Physical biology
pub_type: 杂志文章
doi:10.1088/1478-3967/1/1/004
更新日期:2004-06-01 00:00:00